A new area for biomarkers
Bring High-Definition Medical Imaging Closer to Patients' Needs and unlock the power of blood flow data Discover ResolveTECHNOLOGY, VISION & Applications
Our Technology
The development of our technology could widen applications for macro and microvascular imaging by improving contrast, resolution, and penetration depth of ultrasound. Microbubbles, a contrast agent already clinically used to improve conventional ultrasound imaging, are injected into the blood flow and localized thanks to the ultrasound technology to reconstruct the macro and microvessels.
Building on the results in Olivier Couture’s Laboratory, Resolve is developing an imaging bedside platform, including for neuro applications, to image micro and macro-vessels in 3 dimensions within minutes, allowing its use by many healthcare professionals. Our core technology has already demonstrated its viability in 2D in humans with very high definition images of micro-vessels through the human skull and in 3D in vitro.
Our Vision
In an industry that critically needs innovation, we are constantly impressed by the potential of the Ultrasound Localization Microscopy technology to solve medical challenges. Building a technology that can unlock so many possibilities is the adventure of a lifetime. We know the road ahead will be full of ups and downs. But that makes us even more determined to succeed and make life-changing / saving discoveries possible.
In an industry that critically needs innovation, we are constantly impressed by the potential of the Ultrasound Localization Microscopy technology to solve medical challenges. Building a technology that can unlock so many possibilities is the adventure of a lifetime. We know the road ahead will be full of ups and downs. But that makes us even more determined to succeed and make life-changing / saving discoveries possible.
Our Approach and applications
We now have access to incredibly rich data that has the potential to diagnose stroke and make-life saving discoveries possible. We focus our development toward bedside monitoring. In pre-hospital environment, the studies show the relevance of such imaging for the early diagnosis of stroke in humans, without the constraints and availability of MRI and CT. We hope to have an impact on millions of people, as stroke is considered the second leading cause of death worldwide. Such an imaging device leading to a significant reduction in death and disability thanks to pre-hospital/hospital management of stroke opens a large market.
We now have access to incredibly rich new data that has the potential to diagnose stroke and make-life saving discoveries possible. We focus our development toward bedside monitoring. In pre-hospital environment, the studies show the relevance of such imaging for the early diagnosis of stroke in humans, without the constraints and availability of MRI and CT. We hope to have an impact on millions of people, as stroke is considered the second leading cause of death worldwide. Such an imaging device leading to a significant reduction in death and disability thanks to pre-hospital/hospital management of stroke opens a large market.
Resolve Stroke’s imaging technology could have an impact far beyond stroke management. Blood flow in the Brain is Indicative of Overall Health. Access to blood flow data can prevent disability or death. With more than 200 clinical studies published annually, indications for the use of cerebral ultrasound are expanding !
« Building a technology that can unlock so many possibilities is the adventure of a lifetime. Beyond the early diagnosis of stroke and brain injuries, our technology could solve many medical challenges from early diagnosis of diabetes, to liver monitoring. Many clinical discoveries are expected with the launch of our clinical-ready device. »
Reproduced from A. Chavignon et al., IEEE, 2021 (licenced under CC BY 4.0)
A tech. with outstanding preclinical evidence of Acute stroke triage (2021)
Reproduced from A. Chavignon et al., sci. rep., 2022 (licenced under CC BY 4.0)
Reproduced from A. Chavignon et al., sci. rep., 2022 (licenced under CC BY 4.0)
Stroke
Early Detection and Timely Treatment Save Lives, Drive Better Outcomes and Reimbursement
Sources: Viz.ai, Zhu HF, et al; Calgary Stroke Program. Impact of a stroke unit on length of hospital stay and in-hospital case fatality. Stroke., Ebinger M, et al; Association Between Dispatch of Mobile Stroke Units and Functional Outcomes Among Patients With Acute Ischemic Stroke in Berlin.
ICU & emergency department
Bedside Imaging Save Lives, Drive Better Outcomes, Reduce delays to Transfer Patients and Avoid Unnecessary Costs for Hospitals
Source: Hyperfine.io
About Us
Resolve is clinical-stage medtech, a spin-off from the biomedical imaging Laboratory of the Sorbonne University in Paris. In 2022, Vincent Hingot, Aritz Zamacola and Olivier Couture officially launched the company to supercharge the development of the lab’s promising super ultrasound localisation technology.
Our core technology is the result of over ten years of research around the ultrasound localisation microscopy (ULM). Led by Research Director Olivier Couture’s team, this work revealed new opportunities for medical imaging. A successful demonstration of stroke imaging with small animals confirmed the technology’s perspective for stroke management.
Driven by a powerful ambition to develop a new generation of vascular imaging device to solve unsolved medical issues, we are pioneers in the translation of ULM to humans through the integration of high level hardware and software know-how and technologies. And we are partnering with leading research groups to accomplish this goal.
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Our executive co-founders, Vincent Hingot and Aritz Zamacola bring a unique combination of scientific excellence and business skills to the company. Our team is made up of the most accomplished experts in ULM technology. Our scientific advisor, Olivier Couture, is a renowned scientist and pioneer in super ultrasound localisation.
We are leading next medical imaging ultrasound breakthrough, and we are just getting started.
Meet our cofounders
Aritz Zamacola
CEO & Co-founder
Ex. Roland Berger, core member of the global healthcare practice
MSc Biomedical Engineer, Imperial College, UK
MSc Engineering CentraleSupélec, France
MSc Strategic management, HEC Paris, France
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PhD. Vincent Hingot
CTO & Co-founder
World expert in Biomedical ultrasound and
Super Resolution Imaging
PhD Biomedical Ultrasound, Sorbonne Uni., Fr
MSc Engineering, ESPCI, France
Visiting Student, Harvard University, USA
PhD. Olivier Couture
Scientific advisor & Co-founder
World expert in ultrasound imaging and inventor of Ultrasound Localization Microscopy
Research Director @CNRS and team leader @Laboratoire d’Imagerie Biomédicale
PhD Medical Biophysics, Toronto Uni., Canadax
Key scientific papers
2015: First proof of concept, Nature
Errico, C., Pierre, J., Pezet, S. et al. Ultrafast ultrasoundlocalization microscopy for deep super-resolution vascular imaging.Nature 527, 499–502 (2015).
2018: Seminal review, IEEE TUFFC
Couture O, Hingot V, Heiles B, Muleki-Seya P, Tanter M. Ultrasound Localization Microscopy and Super-Resolution: A State of the Art. IEEE Trans Ultrason Ferroelectr Freq Control. 2018 Aug;65(8):1304-1320. doi: 10.1109/TUFFC.2018.2850811. Epub 2018 Jun 26. PMID: 29994673.
2019: theoretical consolidation, Nature Sci. Rep
Hingot, V., Errico, C., Heiles, B. et al. Microvascular flow dictates the compromise between spatial resolution and acquisition time in Ultrasound Localization Microscopy. Sci Rep 9, 2456 (2019). https://doi.org/10.1038/s41598-018-38349-x.
2019: 3D with full addressed system, IEEE TMI
B. Heiles et al., « Ultrafast 3D Ultrasound Localization Microscopy Using a 32 $\times$ 32 Matrix Array, » in IEEE Transactions on Medical Imaging, vol. 38, no. 9, pp. 2005-2015, Sept. 2019, doi: 10.1109/TMI.2018.2890358.
2020: 2D preclinical stroke models, thno
Hingot V, Brodin C, Lebrun F, Heiles B, Chagnot A, Yetim M, Gauberti M, Orset C, Tanter M, Couture O, Deffieux T, Vivien D. Early Ultrafast Ultrasound Imaging of Cerebral Perfusion correlates with Ischemic Stroke outcomes and responses to treatment in Mice. Theranostics. 2020 Jun 12;10(17):7480-7491. doi: 10.7150/thno.44233. PMID: 32685000; PMCID: PMC7359089.
2021: 3D preclinical with MUX system, IEEE TBME
A. Chavignon, B. Heiles, V. Hingot, C. Orset, D. Vivien and O. Couture, « 3D Transcranial Ultrasound Localization Microscopy in the Rat Brain With a Multiplexed Matrix Probe, » in IEEE Transactions on Biomedical Engineering, vol. 69, no. 7, pp. 2132-2142, July 2022, doi: 10.1109/TBME.2021.3137265.
2022: 2D performance validation, Nature BME
Heiles B, Chavignon A, Hingot V, Lopez P, Teston E, Couture O. Performance benchmarking of microbubble-localization algorithmsfor ultrasound localization microscopy. Nat Biomed Eng. 2022 May;6(5):605-616. doi: 10.1038/s41551-021-00824-8. Epub 2022 Feb17. PMID: 35177778.
2022: 3D preclinical whole brain, IEEE Open UFFC
B. Heiles et al., « Volumetric Ultrasound Localization Microscopy of the Whole Rat Brain Microvasculature, » in IEEE Open Journal of Ultrasonics, Ferroelectrics, and Frequency Control, vol. 2, pp. 261-282, 2022, doi: 10.1109/OJUFFC.2022.3214185.
2022: 3D preclinical stroke, Nature Sci. Rep
Chavignon, A., Hingot, V., Orset, C. et al. 3D transcranial ultrasound localization microscopy for discrimination betweenischemic and hemorrhagic stroke in early phase. Sci Rep 12, 14607 (2022). https://doi.org/10.1038/s41598-022-18025-x.
CREATING CHANGE TOGETHER
Claude Cohen-Bacrie
Founder and CEO of E-scopics
Founder & former CTO, Executive VP
@SuperSonic Imagine
Developper of the UltraFast platform
that can acquire images +100 times faster than conventional ultrasound systems
Former Group leader Philips Research USA
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Pr. Denis Vivien
Hospital Practitioner and Professor @Caen-Normandie University / Caen-Normandie Hospital
Head of Diagnostics and Therapeutic Innovations
Managing director @ BB@C
Director INSERM-UNICAEN « Physiology and Imaging of Neurological Disorders »
Scientific director of the IBiSA “Experimental Stroke Research-Recovery-Resources platform » and expert for AVC at AVIESAN.
MD, Sylvain Bodard
Radiologist - Chef de Clinique @Necker (APHP)
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PhD., PU-PH Clément Gakuba
Anaesthetist-intensive care doctor @CHU Caen - Co-organizer of the Resolve Stroke's clinical trial
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PhD. Olivier Couture
Scientific advisor & Co-founder of Resolve Stroke
World expert in ultrasound imaging and inventor of Ultrasound Localization Microscopy
+ 20 years’ experience with Ultrasound
+40 publications & +10 patents
Research Director @CNRS and team leader @Laboratoire d’Imagerie Biomédicale @Sorbonne Université
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Work with Us
Join a team with extraordinary ambition and talent
Our values
Excellence
To solve one of the most exciting technological challenges in the medical imaging sector, we work with the best talent & partners who can achieve great science and fast results.
Scientific Integrity
We take trust and reliability seriously, from the medical devices we develop to the information we share.
Diversity
We believe the top performing teams are the most diverse, and are committed to building a team with gender and background diversity.
Care
We are invested in solving the world’s biggest problems and nurturing the culture of our company.
Curiosity
We are driven by a strong desire to understand and solve the most complex challenges.
*Submit a general application telling us why you’d love to work with us and we will get in touch if there is a match
Contact Us
Resolve Stroke
Agoranov, 96 bis Boulevard Raspail
75006 Paris, France
Saint Placide : M° ligne 4
Notre-Dame-des-Champs : M° ligne 12