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Lead the next medical imaging leap and make life-saving discoveries possible

Discover Resolve

TECHNOLOGY, VISION & Applications

Our Technology

The development of Ultrasound Localization Microscopy (ULM) could widen applications for microvascular imaging by improving contrast, resolution, and penetration depth. Microbubbles, a contrast agent already clinically used to improve conventional ultrasound imaging, are injected into the blood flow and localized thanks to the ultrasound technology to reconstruct the microvessels.


Building on the first results of 3D ULM with small animals in 2018 in Olivier Couture’s Laboratory, Resolve is developing an imaging bedside platform based on ULM technology to image micro and macro-vessels in 3 dimensions within minutes, allowing its use by many healthcare professionals. Our core technology has already demonstrated its viability in 2D in humans with very high definition images of micro-vessels through the human skull and in 3D in vitro.

Our Vision

In an industry that critically needs innovation, we are constantly impressed by the potential of the Ultrasound Localization Microscopy (ULM) technology to solve medical challenges. Building a technology that can unlock so many possibilities is the adventure of a lifetime. We know the road ahead will be full of ups and downs. But that makes us even more determined to succeed and make life-changing / saving discoveries possible.

In an industry that critically needs innovation, we are constantly impressed by the potential of the Ultrasound Localization Microscopy (ULM) technology to solve medical challenges. Building a technology that can unlock so many possibilities is the adventure of a lifetime. We know the road ahead will be full of ups and downs. But that makes us even more determined to succeed and make life-changing / saving discoveries possible.

Our Approach and applications

We now have access to incredibly rich data that has the potential to diagnose stroke and make-life saving discoveries possible. We focus our development toward the application of 3D ULM for non-invasive stroke diagnosis and aneurysm monitoringThe first studies show the relevance of such imaging for the early diagnosis of stroke in humans by volumetric ULM, without the constraints and availability of MRI and CT. By targeting stroke first, we hope to have an impact on millions of people, as stroke is considered the second leading cause of death worldwide. Such an imaging device leading to a significant reduction in death and disability thanks to pre-hospital/hospital management of stroke opens a large market.

We now have access to incredibly rich new data that has the potential to diagnose stroke and make-life saving discoveries possible. We focus our development toward the application of 3D ULM for non-invasive stroke diagnosis and aneurysm monitoringThe first studies show the relevance of such imaging for the early diagnosis of stroke in humans by volumetric ULM, without the constraints and availability of MRI and CT. By targeting stroke first, we hope to have an impact on millions of people, as stroke is considered the second leading cause of death worldwide. Such an imaging device leading to a significant reduction in death and disability thanks to pre-hospital/hospital management of stroke opens a large market.

3D ULM imaging technology could have an impact far beyond stroke management. Blood flow in the Brain is Indicative of Overall Health. Access to blood flow data can prevent disability or death. With more than 200 clinical studies published annually, indications for the use of cerebral ultrasound are expanding !

« Building a technology that can unlock so many possibilities is the adventure of a lifetime. Beyond the early diagnosis of stroke and brain injuries, 3D ULM could solve many medical challenges from early diagnosis of diabetes, to liver monitoring. Many clinical discoveries are expected with the launch of our clinical-ready device. »

Reproduced from A. Chavignon et al., IEEE, 2021 (licenced under CC BY 4.0)

A tech. with outstanding preclinical evidence of Acute stroke triage (2021)

Reproduced from A. Chavignon et al., sci. rep., 2022 (licenced under CC BY 4.0)

Reproduced from A. Chavignon et al., sci. rep., 2022 (licenced under CC BY 4.0)

About Us

Resolve is clinical-stage medtech, a spin-off from the biomedical imaging Laboratory of the Sorbonne University in Paris. In May 2022, Vincent Hingot, Aritz Zamacola and Olivier Couture officially launched the company to supercharge the development of the lab’s promising super ultrasound localisation technology.

Our core technology is the result of over ten years of research around the ultrasound localisation microscopy (ULM). Led by Research Director Olivier Couture’s team, this work revealed new opportunities for medical imaging. A successful demonstration of stroke imaging with small animals confirmed the technology’s perspective for stroke management.

Driven by a powerful ambition to develop a new generation of vascular imaging device to solve unsolved medical issues, we are pioneers in the translation of ULM to humans through the integration of high level hardware and software know-how and technologies. And we are partnering with leading research groups to accomplish this goal.

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Our executive co-founders, Vincent Hingot and Aritz Zamacola bring a unique combination of scientific excellence and business skills to the company. Our team is made up of the most accomplished experts in ULM technology. Our scientific advisor, Olivier Couture, is a renowned scientist and pioneer in super ultrasound localisation.

We are leading next medical imaging ultrasound breakthrough, and we are just getting started.

Stroke 


Early Detection and Timely Treatment Save Lives, Drive Better Outcomes and Reimbursement

Sources: Viz.ai, Zhu HF, et al; Calgary Stroke Program. Impact of a stroke unit on length of hospital stay and in-hospital case fatality. Stroke., Ebinger M, et al; Association Between Dispatch of Mobile Stroke Units and Functional Outcomes Among Patients With Acute Ischemic Stroke in Berlin. 

ICU & emergency department

Bedside Imaging Save Lives, Drive Better Outcomes, Reduce delays to Transfer Patients and Avoid Unnecessary Costs for Hospitals

Source: Hyperfine.io

Meet our team

Aritz Zamacola

Aritz Zamacola

CEO & Co-founder

Ex. Roland Berger, core member of the global healthcare practice
MSc Biomedical Engineer, Imperial College, UK
MSc Engineering CentraleSupélec, France
MSc Strategic management, HEC Paris, France
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PhD. Vincent Hingot

PhD. Vincent Hingot

CTO & Co-founder

World expert in Biomedical ultrasound and
Super Resolution Imaging

PhD Biomedical Ultrasound, Sorbonne Uni., Fr
MSc Engineering, ESPCI, France
Visiting Student, Harvard University, USA

PhD. Olivier Couture

PhD. Olivier Couture

Scientific advisor & Co-founder

World expert in ultrasound imaging and inventor of Ultrasound Localization Microscopy
Research Director @CNRS and team leader @Laboratoire d’Imagerie Biomédicale
PhD Medical Biophysics, Toronto Uni., Canadax

PhD. Arthur Chavignon

PhD. Arthur Chavignon

R&D software engineer

Expert in Biomedical ultrasound and Super Resolution Imaging. Co-developper of the 3D super Resolution Imaging software

PhD Biomedical Ultrasound, Sorbonne Université, Fr
MSc Engineering CentraleSupélec, France

 

Anne-Sophie Germain

Anne-Sophie Germain

Product engineer

Former engineer
for ultrasound device manufacturer 

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MSc Engineering ICAM, France

 

PhD. Maxence Reberol

PhD. Maxence Reberol

Lead software engineer

Expert in 3D modelingx

PhD Computer Science, Inria, Fr
MSc Engineering CentraleSupélec, France

 

PhD. Leo Gury

PhD. Leo Gury

R&D hardware engineer / regulatory expert

Expert in regulatory affairs for Biomedical ultrasound device xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx

PhD Material Science
MSc Engineering ESPCI, France

 

Key scientific papers

2015: First proof of concept, Nature

Errico, C., Pierre, J., Pezet, S. et al. Ultrafast ultrasoundlocalization microscopy for deep super-resolution vascular imaging.Nature 527, 499–502 (2015). 

2018: Seminal review, IEEE TUFFC

Couture O, Hingot V, Heiles B, Muleki-Seya P, Tanter M. Ultrasound Localization Microscopy and Super-Resolution: A State of the Art. IEEE Trans Ultrason Ferroelectr Freq Control. 2018 Aug;65(8):1304-1320. doi: 10.1109/TUFFC.2018.2850811. Epub 2018 Jun 26. PMID: 29994673.

2019: theoretical consolidation, Nature Sci. Rep

Hingot, V., Errico, C., Heiles, B. et al. Microvascular flow dictates the compromise between spatial resolution and acquisition time in Ultrasound Localization Microscopy. Sci Rep 9, 2456 (2019). https://doi.org/10.1038/s41598-018-38349-x.

 

2019: 3D with full addressed system, IEEE TMI

B. Heiles et al., « Ultrafast 3D Ultrasound Localization Microscopy Using a 32  $\times$  32 Matrix Array, » in IEEE Transactions on Medical Imaging, vol. 38, no. 9, pp. 2005-2015, Sept. 2019, doi: 10.1109/TMI.2018.2890358.

 

2020: 2D preclinical stroke models, thno

Hingot V, Brodin C, Lebrun F, Heiles B, Chagnot A, Yetim M, Gauberti M, Orset C, Tanter M, Couture O, Deffieux T, Vivien D. Early Ultrafast Ultrasound Imaging of Cerebral Perfusion correlates with Ischemic Stroke outcomes and responses to treatment in Mice. Theranostics. 2020 Jun 12;10(17):7480-7491. doi: 10.7150/thno.44233. PMID: 32685000; PMCID: PMC7359089.

 

2021: 3D preclinical with MUX system, IEEE TBME

A. Chavignon, B. Heiles, V. Hingot, C. Orset, D. Vivien and O. Couture, « 3D Transcranial Ultrasound Localization Microscopy in the Rat Brain With a Multiplexed Matrix Probe, » in IEEE Transactions on Biomedical Engineering, vol. 69, no. 7, pp. 2132-2142, July 2022, doi: 10.1109/TBME.2021.3137265.

 

2022: 2D performance validation, Nature BME

Heiles B, Chavignon A, Hingot V, Lopez P, Teston E, Couture O. Performance benchmarking of microbubble-localization algorithmsfor ultrasound localization microscopy. Nat Biomed Eng. 2022 May;6(5):605-616. doi: 10.1038/s41551-021-00824-8. Epub 2022 Feb17. PMID: 35177778.

 

2022: 3D preclinical whole brain, IEEE Open UFFC

B. Heiles et al., « Volumetric Ultrasound Localization Microscopy of the Whole Rat Brain Microvasculature, » in IEEE Open Journal of Ultrasonics, Ferroelectrics, and Frequency Control, vol. 2, pp. 261-282, 2022, doi: 10.1109/OJUFFC.2022.3214185.

 

2022: 3D preclinical stroke, Nature Sci. Rep

Chavignon, A., Hingot, V., Orset, C. et al. 3D transcranial ultrasound localization microscopy for discrimination betweenischemic and hemorrhagic stroke in early phase. Sci Rep 12, 14607 (2022). https://doi.org/10.1038/s41598-022-18025-x.

 

CREATING CHANGE TOGETHER

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Work with Us

Join a team with extraordinary ambition and talent

Our values

Excellence

To solve one of the most exciting technological challenges in the medical imaging sector, we work with the best talent & partners who can achieve great science and fast results.

Scientific Integrity

We take trust and reliability seriously, from the medical devices we develop to the information we share.

Diversity

We believe the top performing teams are the most diverse, and are committed to building a team with gender and background diversity.

Care

We are invested in solving the world’s biggest problems and nurturing the culture of our company.

Curiosity

We are driven by a strong desire to understand and solve the most complex challenges.

*Submit a general application telling us why you’d love to work with us and we will get in touch if there is a match

Contact Us


Resolve Stroke

Agoranov, 96 bis Boulevard Raspail
75006 Paris, France


Saint Placide : M° ligne 4
Notre-Dame-des-Champs : M° ligne 12

Let’s get in touch